The Effect of Exercise on Leptin and Adiposity: A Systematic Review

Introduction: Leptin has been characterized as an important regulator of metabolic homeostasis, functioning in the inhibition food intake and promotion energy expenditure. resistance implicated development cardiovascular diseases obesity, exercise programs are used a therapeutic measure for these disorders, it is hypothesized that will decrease concentrations leptin blood. Methods: A comprehensive literature search MedLine was conducted from inception to September 2020. Relevant terms include: Leptin, Obesity, Exercise, Physical activity, BMI, Adiposity. Eligible randomized control trials (RCTs) include RCTs reporting on effects low, moderate or high intensive concentration. We followed strategy based PRISMA report our systematic review, assessed studies independently duplicate their risk bias (ROB) using Cochrane ROB2 tool. Statistical analysis performed compare ROB (categorized “high” “low/some”) relation impact factor, number citations, authors. Results: Forty-eight involving relationship between physical met inclusion criteria. After completing ROB, relationships factor (0.2775, p > 0.6405), citation (2.059, 0.0962), authors (-5.235, 0.5551) were determined. Discussion: The pathway involves overactivation mTOR contributing with this being inhibited by activity. This corresponds findings thirty-nine reported resulted statistically significant levels compared group. However, overall evidence insufficient suggest number, Conclusion: review indicated inverse further research needed address varying activity define more concrete characteristics field.